|
|
| Gene : |
CCND1 |
| Gene ID : |
595 |
| Uniprot ID : |
P24385 |
| Alternative Name : |
CCND1, BCL1, PRAD1 |
| Format : |
Purified |
| Amount : |
0.5 ml |
| Clone name : |
DCS-6 |
| Isotype : |
Mouse IgG2a, kappa |
| Immunogen Information : |
Human recombinant full length cyclin D1 protein |
Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Flow Cytometry (5ul per test per one million cells or 5ul per 100ul of whole blood);Immunofluorescence (1:50-1:100 for 30 minutes at RT)
