|
|
| Gene : |
CYCS |
| Gene ID : |
54205 |
| Uniprot ID : |
P99999 |
| Alternative Name : |
CYCS, CYC |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ABM30B3 |
| Isotype : |
Mouse IgG2b Kappa |
| Immunogen Information : |
Full length recombinant Cytochrome C protein was used as the immunogen for this antibody. |
Cytochrome C is an inner mitochondrial membrane hemeprotein encoded by CYCS gene. Cytochrome C has two major roles within the cell; firstly, it acts as an electron carrier between Complex III (Cytochrome bc1 complex) and Complex IV (Cytochrome C oxidase). The second important function of Cytochrome C is in apoptosis. In response to extrinsic or intrinsic signals and upon suppression of anti-apoptotic molecules, several pro-apoptotic molecules are activated that disturb the mitochondrial membrane permeability and causes the release of Cytochrome C. Cytochrome C then binds to apoptotic protease activating factor-1 (Apaf-1). This complex interacts with pro-caspase 9 and initiates the caspase cascade resulting in apoptosis. Human Cytochrome C has a molecular mass of 11 kDa. Defect in the CYCS gene is associated with autosomal dominant diseases like thrombocytopenia type 4 (THC4). High levels of Cytochrome C are found in blood leukocytes, kidney, liver, heart and brain.
Western blot analysis:2-4 µg/ml; FACS Analysis: 0.5-1 µg/10^6 cells
