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|
Gene : |
KRT19 |
Gene ID : |
3880 |
Uniprot ID : |
P08727 |
Alternative Name : |
KRT19 |
Format : |
Purified |
Amount : |
100 µg |
Clone name : |
A53-B/A2.26 + BA17 |
Isotype : |
Mouse IgG2a, lambda + Mouse IgG1, kappa |
Immunogen Information : |
Human breast cancer MCF-7 cells (A53-B/A2); Human mammary epithelial organoids (BA17) |
This MAb reacts with the rod domain of human cytokeratin-19 (CK19), a polypeptide of 40kDa. CK19 is expressed in sweat gland, mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, and ectocervical epithelium. Anti-CK19 reacts with a wide variety of epithelial malignancies including adenocarcinomas of the colon, stomach, pancreas, biliary tract, liver, and breast. Perhaps the most useful application is the identification of thyroid carcinoma of the papillary type, although 50%-60% of follicular carcinomas are also labeled. Anti-CK19 is a useful marker for detection of tumor cells in lymph nodes, peripheral blood, bone marrow and breast cancer.
Western Blot (1-2ug/ml);Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);