|
|
| Gene : |
CD209 |
| Gene ID : |
30835 |
| Uniprot ID : |
Q9NNX6 |
| Alternative Name : |
CD209, CLEC4L |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ABM47B7 |
| Isotype : |
Mouse IgG2b Kappa |
| Immunogen Information : |
A recombinant protein fragment of DC-Sign protein was used as the immunogen for this antibody. |
Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is a tetrameric C-type (calcium-dependent) lectin that binds, through its C-terminal carbohydrate recognition domain, high mannose N-linked glycans present on the surface of several viral glycoproteins such as human immunodeficiency virus (HIV) gp120 and hepatitis C virus (HCV) E2. It facilitates DC-specific delivery of Ag. This is accomplished by conjugating Ag to receptor-specific Ab or carbohydrate ligands that bind to its carbohydrate recognition domain. In humans, DC-SIGN expression is restricted to DCs and certain types of macrophages. DC-SIGN is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens, including viruses, bacteria, fungi, and parasites. After binding, these pathogens are internalized and pathogen-derived antigens are presented via MHC class I and II molecules to CD8+ and CD4+ T cells, respectively. DC-SIGN represents a promising CLR for targeted vaccine delivery.
Western blot analysis: 0.1-0.5 µg/ml; FACS: 0.5-1 µg/10^6 Cells
Reference for expression of Dc-Sign:
Wai K. Lai, Phoebe J. Sun, Jie Zhang, Adam Jennings, Patricia F. Lalor, Stefan Hubscher,Jane A. McKeating,and David H. Adams. Expression of DC-SIGN and DC-SIGNR on Human Sinusoidal Endothelium Am J Pathol. 2006 Jul; 169(1): 200–208.doi: 10.2353/ajpath.2006.051191
