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Gene : |
CLEC6A |
Gene ID : |
93978 |
Uniprot ID : |
Q6EIG7 |
Alternative Name : |
CLEC6A, CLECSF10, DECTIN2 |
Format : |
Purified |
Amount : |
100 µg |
Clone name : |
ABM2H28 |
Isotype : |
Mouse IgG2a Kappa |
Immunogen Information : |
A partial length recombinant Dectin-2 protein (amino acids 70-230) was used as the immunogen for this antibody. |
Dectin-2 (C-type lectin domain family 6 member A) is a type II membrane receptor with an extracellular C-type lectin-like domain fold. Dectin-2 plays an important role in the host defense against C. albicans infection by inducing TH17 cell differentiation. It binds high-mannose carbohydrates in a Ca(2+)-dependent manner. In Dectin-2 glycosylation occurs at Asn131, Asn170. Dectin-2 has 2 isoforms produced by alternative splicing. Dectin-2 is strongly expressed in monocytes and weakly in B-cells and also expressed in spleen, tonsils, lymph node, lungs, leukocytes, dendritic cells and bone marrow.
Western blot analysis: 2-4 µg/ml, FACS analysis: 0.5 µg/10^6 cells, Immunohistochemical analysis: 5 µg/ml