|
|
| Gene : |
CDH1 |
| Gene ID : |
999 |
| Uniprot ID : |
P12830 |
| Alternative Name : |
CDH1, CDHE, UVO |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ABM43F8 |
| Isotype : |
Mouse IgG1 Kappa |
| Immunogen Information : |
A partial length recombinant E-cadherin protein (amino acids 438-556) was used as the immunogen for this antibody . |
Epithelial cadherin (E-cadherin) is a calcium dependent cell-cell adhesion glycoprotein. It is associated with gland formation, stratification, and epithelial polarization. Its deregulation affects cell-cell adhesion and results in increased invasiveness of distinct human carcinomas like gastric cancer, malignancy, oral squamous cell carcinoma, Atypical parathyroid adenoma (APA). Loss of function of E-cadherin leads to the disappearance of epithelial characteristics of the cells and generates higher invasiveness for extracellular matrices. E-cadherin expression is considered to be a decisive indicator for differentiation, aggressive behaviour, high proliferation, metastasis, poor prognosis and invasiveness of human carcinoma cells.
Western blot analysis: 4-6 µg/ml, Immunohistochemical analysis: 5-15 µg/ml
