|
|
Gene : |
ESR1 |
Gene ID : |
2099 |
Uniprot ID : |
P03372 |
Alternative Name : |
ESR1, ESR, NR3A1 |
Format : |
Purified |
Amount : |
100 µg |
Clone name : |
ER505 |
Isotype : |
Mouse IgG1 Kappa |
Immunogen Information : |
Recombinant human Estrogen Receptor alpha protein (aa2-185) |
This MAb is specific to ER alpha and shows minimal cross-reaction with other members of the family. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy. This MAb is excellent for staining of formalin-fixed, paraffin-embedded breast carcinomas.
Western Blot (0.5-1µg/ml for 2 hours at Room Temp); Immunohistology (Formalin-fixed) (1-2µg/ml for 30 minutes at RT); (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined.