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|
| Gene : |
SLC40A1 |
| Gene ID : |
30061 |
| Uniprot ID : |
Q9NP59 |
| Alternative Name : |
SLC40A1, FPN1, IREG1, SLC11A3, MSTP079 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ABM51D1 |
| Isotype : |
Mouse IgG2b Kappa |
| Immunogen Information : |
A partial length recombinant protein from N terminal portion of Ferroportin 1 was used as the immunogen for this antibody. |
Ferroportin-1, a principal iron exporter, is involved in transporting iron from the duodenum to the serum, and in iron recycling from reticuloendothelial macrophages into the circulation, respectively. Hepcidin, the key mediator of iron homeostasis produced by liver, negatively controls ferroportin-1 expression levels by a posttranslational mechanism. Ferroportin-1 is found on the basolateral surface of enterocytes and the macrophage cell wall. Dietary iron absorbed by enterocytes is moved into the circulation by ferroportin-1, then circulates are bound to transferrin and delivered to tissues via endocytosis of the iron/transferrin complex. Mutations in ferroportin-1 causes impaired ferroportin delivery to the plasma membrane or decreased iron transport and results in macrophage iron retention whereas others render ferroportin insensitive to hepcidin and cause systemic iron overload. Some of the classical ferroportin disease is characterized by hyperferritinemia, normal transferrin saturation, and iron overload in macrophages.
Western blot analysis: 2-4µg/ml
