|
|
| Gene : |
IL23R |
| Gene ID : |
149233 |
| Uniprot ID : |
Q5VWK5 |
| Alternative Name : |
Interleukin-23 receptor, IL-23 receptor, IL-23R |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ABM25G4 |
| Isotype : |
Mouse IgG1, Kappa |
| Immunogen Information : |
A partial length recombinant protein (a.a 250-450) of IL-23R was used as the immunogen for this antibody. |
IL-23, a member of the IL-12 cytokine family, is composed of a p40 subunit, which is shared with IL-12, and a p19 subunit, with an approximate molecular weight of 60 kDa. IL-23 is produced by activated dendritic cells and macrophages in response to microorganisms. IL-23 promotes Th17 cells producing TNF-a, IL-17, IL-6, IL-22, GM-CSF, and other novel factors, which are associated with the induction of autoimmune inflammation. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling pathway. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis, primary biliary cirrhosis, and inflammatory bowel disease.
Western blot analysis: 1-2 µg/ml, Flowcytometric analysis: 2-4 µg/10^6 cells
