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Gene : |
IL3RA |
Gene ID : |
3563 |
Uniprot ID : |
P26951 |
Alternative Name : |
Interleukin-3 receptor subunit alpha, IL-3 receptor subunit alpha, CD123, IL-3R-alpha |
Format : |
Purified |
Amount : |
100 µg |
Clone name : |
ABM25C1 |
Isotype : |
Mouse IgG2b, Kappa |
Immunogen Information : |
A partial length recombinant protein (a.a 120-323) of IL-3RA was used as the immunogen for this antibody. |
Interleukin-3 receptor subunit alpha (IL-3RA) or CD123 is a high-affinity receptor for interleukin-3 (IL-3), which along with the primary signaling common β (βc) subunit (CD131) forms a heterodimer, enabling cell signaling. IL-3RA chain is a glycoprotein of 360 amino acidic residues, composed by an extracellular domain of 287 amino acid residues, involving a predicted Ig-like domain, two Fn III domains, a transmembrane domain of 30 amino acid residues and by an intracellular domain of 53 residues. It is expressed on the majority of CD34+ hemopoietic progenitors and its expression is rapidly lost during erythroid and megakaryocytic differentiation, moderately decreased during monocytic differentiation and is sustained in the granulocytic lineage. IL-3RA is also expressed in a variety of hematological neoplasms including blastic plasmacytoid dendritic cell neoplasm (BPDCN), acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), Hodgkin’s lymphoma and hairy cell leukemia.
WB: 6-8 µg/ml, FACS: 0.5-1 µg/10^6