|
|
| Gene : |
XRCC6 |
| Gene ID : |
2547 |
| Uniprot ID : |
P12956 |
| Alternative Name : |
XRCC6, G22P1 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
KU729 |
| Isotype : |
Mouse IgG1, kappa |
| Immunogen Information : |
Nuclear extract of human HL-60 cells |
Recognizes a dimer of two proteins of 70kDa and ~80kDa, identified as two subunits of Ku. This MAb recognizes a conformational epitope of p70/p80 dimer, which is destroyed during Western blotting. The p70/p80 dimer is important for function of a 460kDa DNA-dependent protein kinase. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml); ,Immunocytochemistry (Acetone-fixed cells) (0.5-1.0ug/ml for 30 minutes at RT),
