|
|
| Gene : |
MCAM |
| Gene ID : |
4162 |
| Uniprot ID : |
P43121 |
| Alternative Name : |
MCAM, MUC18 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
MUC18/1130 |
| Isotype : |
Mouse IgG1, kappa |
| Immunogen Information : |
Recombinant human MUC18 protein |
The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.
Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml); Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 1mM EDTA, pH 8.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
