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|
| Gene : |
MUL1 |
| Gene ID : |
79594 |
| Uniprot ID : |
Q969V5 |
| Alternative Name : |
MUL1, C1orf166, GIDE, MAPL, MULAN, RNF218 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ABM4F71 |
| Isotype : |
Mouse IgG1, kappa |
| Immunogen Information : |
A partial length recombinant MUL1 protein (amino acids 146-352) was used as the immunogen for this antibody. |
MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase-1) is a crucial moderator of RIG-I (Retinoic Acid-Inducible-Gene-I) signaling. This protein is localized to the mitochondria where it interacts with MAVS (Mitochondrial Antiviral Signaling) and catalyzes RIG-I post-translational modifications that inhibit RIG-I-dependent cell signaling. MUL1 contains a unique BAM (Beside A Membrane) domain and a C-terminal RING-finger domain. This protein has been implicated in several processes that occur in animal cells such as NF-KappaB activation, innate immunity and antiviral signaling, suppression of PINK1/parkin defects, mitophagy in skeletal muscle, and caspase-dependent apoptosis.
Western blot analysis: 4-8 µg/ml
