|
|
| Gene : |
PAX7 |
| Gene ID : |
5081 |
| Uniprot ID : |
P23759 |
| Alternative Name : |
PAX7, HUP1 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
PAX7/1187 |
| Isotype : |
Mouse IgG1 Kappa |
| Immunogen Information : |
Recombinant fragment (aa300-600) of human PAX7 protein |
The Pax gene family of nuclear transcription factors is comprised of nine members that function during embryogenesis to regulate the temporal and position-dependent differentiation of cells. In addition, the family is involved in a variety of signal transduction pathways in the adult organism. Mutations in the Pax family of proteins have been linked to disease and cancer in humans. Pax-7 is a protein specifically expressed in cultured satellite cell-derived myoblasts. In situ hybridization reveals that Pax-7 is also expressed in satellite cells residing in adult muscle. A chromosomal aberration in the gene encoding Pax-7 causes rhabdomyosarcoma 2 (RMS2) (also called alveolar rhabdomyosarcoma).
Immunohistology (Formalin-fixed) (0.5-1µg/ml for 30 minutes at RT); (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris Buffer with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined.
