|
|
| Gene : |
TNNI3 |
| Gene ID : |
7137 |
| Uniprot ID : |
P19429 |
| Alternative Name : |
TNNI3, TNNC1 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ABM49D9 |
| Isotype : |
Mouse IgG2b Kappa |
| Immunogen Information : |
A partial length recombinant protein from N terminal portion of Troponin 1 was used as the immunogen for this antibody. |
Troponin I (TNNI3) plays a key role in the regulation of contraction and relaxation. As part of the thin filament, the troponin complex (cTnI, troponin T [TnT], and troponin C [TnC]), along with tropomyosin, regulates the actin filament interaction with the thick filament (composed primarily of myosin) in a Ca2+-dependent manner. Human troponin I can be phosphorylated at multiple amino acid residues, S22, S23, T30, S41, S43, S76, T77, T142, S149, and S165 (the numbering excludes the initiating methionine), and studies have shown that phosphorylation at different residues can alter function. Troponin I along with troponin T is found in heart muscle and is released into the blood when there is damage to the heart. Troponin tests are also sometimes used to evaluate people for heart injury due to causes other than a heart attack or to distinguish signs and symptoms such as chest pain that may be due to other causes.
Western blot analysis: 0.5-1 µg/ml; Immunohistochemestry: 5-10 µg/ml
