|
|
| Gene : |
TYRP1 |
| Gene ID : |
7306 |
| Uniprot ID : |
P17643 |
| Alternative Name : |
TYRP1, CAS2, TYRP, TYRRP |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
TYRP1/807 |
| Isotype : |
Mouse IgG2a, kappa |
| Immunogen Information : |
Recombinant full-length human TYRP1 protein |
It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.?Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
Immunohistochemistry (Formalin-fixed) (3-6ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
