|
|
| Gene : |
ESR1 |
| Gene ID : |
2099 |
| Uniprot ID : |
P03372 |
| Alternative Name : |
ER-alpha |
| Format : |
Purified |
| Amount : |
1 mg |
| Clone name : |
LSERASC1. |
| Isotype : |
Mouse IgG. |
| Immunogen Information : |
Recombinant human ER-alpha. |
Estrogen receptors ? (ER?, ER; NR3A1) is a member of the steroid hormone receptor family. ER? is a ligand-activated transcription factor. ER? contain DNA binding and ligand binding domains. ER? is expressed in a wide variety of tissues, including ovary, uterus, breast, prostate, testis, epididymis, bones, bladder, kidney, heart, vessel wall, pituitary gland and hypothalamus. ER plays a variety of important roles in the maintenance of the reproductive, cardiovascular, musculoskeletal and central nervous systems. The natural ligand for ER is 17?-estradiol, the classical estrogenic compound. The binding of estrogen to ER induces a conformational change and triggers a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes.
