|
|
| Gene : |
ING2 |
| Gene ID : |
3622 |
| Uniprot ID : |
Q9H160 |
| Alternative Name : |
Inhibitor Of Growth Family Member 2, ING1L, Inhibitor Of
Growth 1-Like Protein, P33ING2, ING1Lp, P32, Inhibitor Of Growth Family Member
1-Like, Inhibitor Of Growth Protein 2, ING2. |
| Format : |
Purified |
| Amount : |
20 µg |
| Clone name : |
PAT39E5AT |
| Isotype : |
Mouse IgG1 heavy chain and k light chain. |
| Immunogen Information : |
Anti-human ING2 mAb,
clone PAT39E5AT, is derived from hybridization of mouse F0 myeloma cells with
spleen cells from BALB/c mice immunized with a recombinant human ING2 protein 1-280
amino acids purified from E. coli. |
Inhibitor of Growth Family, Member 2 (ING2) belongs to the inhibitor of growth (ING) family. ING family members associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and serve in DNA repair and apoptosis. ING2 appears to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, most likely by enhancing acetylation of p53/TP53. ING2 is a component of an mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity is modulated by binding to phosphoinositides (PtdInsPs).
The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000.
