|
|
| Gene : |
SERPINF1 |
| Gene ID : |
5176 |
| Uniprot ID : |
P36955 |
| Alternative Name : |
Pigment epithelium-derived factor, PEDF,
Serpin-F1, SerpinF1, EPC-1, EPC1, PIG35. |
| Format : |
Purified |
| Amount : |
20 µg |
| Clone name : |
P1C4AT. |
| Isotype : |
Mouse IgG1 heavy chain and ? light chain. |
| Immunogen Information : |
Anti-human PEDF mAb, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with Recombinant human PEDF amino acids 19-418 purified from E. coli. |
PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. PEDF is a 50,000 dalton glycoprotein created and secreted in many tissues all the way through the body. A key component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. Additionally, PEDF is capable to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuro-protective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recognition of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities associate it as a potential therapeutic agent for the treatment of vasculature related neurode
PEDF antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 2,000. Recommended starting dilution is 1:1,000.
