|
|
| Gene : |
PPM1F |
| Gene ID : |
9647 |
| Uniprot ID : |
P49593 |
| Alternative Name : |
Protein phosphatase 1F, Ca(2+)/calmodulin-dependent
protein kinase phosphatase, CaM-kinase phosphatase, CaMKPase, Partner of PIX 2,
Protein fem-2 homolog, hFem-2, KIAA0015, POPX2, PPM1F, CAMKP, FEM-2. |
| Format : |
Purified |
| Amount : |
20 µg |
| Clone name : |
PAT6D11AT |
| Isotype : |
Mouse IgG1 heavy chain and k light chain. |
| Immunogen Information : |
Anti-human PPM1F mAb,
clone PAT6D11AT, is derived from hybridization of mouse F0 myeloma cells with
spleen cells from BALB/c mice immunized with a recombinant human PPM1F protein 1-454
amino acids purified from E. coli. |
Protein Phosphatase 1F (PPM1F) is a part of the PP2C family of Ser/Thr protein phosphatases whose members are known to be negative regulators of cell stress response pathways. PPM1F interacts with Rho guanine nucleotide exchange factors (PIX), and as a result blocks the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is one of the substrates of PPM1F. PPM1F is found to be an apoptosis Promoter.
The
antibody has been tested by ELISA, Western blot analysis to assure specificity
and reactivity. Since application varies, however, each investigation should be
titrated by the reagent to obtain optimal results. Recommended starting
dilution is 1:1000.
