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| Alternative Name : |
TNF-alpha, Tumor necrosis factor ligand superfamily
member 2, TNF-a, Cachectin, DIF, TNFA, TNFSF2. |
| Format : |
Purified |
| Amount : |
20 µg |
| Clone name : |
P10A7AT |
| Isotype : |
Mouse
IgG2b heavy chain and k light chain. |
| Immunogen Information : |
Anti-human TNF-a mAb, clone P10A7AT,
is derived from hybridization of mouse F0 myeloma cells with spleen cells from
BALB/c mice immunized with a recombinant human TNF-a
protein 57-233 amino acids purified from E. coli. |
Tumor necrosis factor is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction. TNF is mainly secreted by macrophages.TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tumorigenesis and viral replication, TNF is also involved in lipid metabolism, and coagulation. TNF's primary role is in the regulation of immune cells.Dysregulation and, in particular, overproduction of TNF have been implicated in a variety of human diseases- autoimmune diseases, insulin resistance, and cancer.
The antibody has been tested by ELISA, Western blot
analysis to assure specificity and reactivity. Since application varies,
however, each investigation should be titrated by the reagent to obtain optimal
results. Recommended starting dilution is 1:100.
