|
|
| Gene : |
HOXA9 |
| Gene ID : |
3205 |
| Uniprot ID : |
P31269 |
| Alternative Name : |
HOXA9, HOX1G |
| Format : |
Purified |
| Amount : |
100 µg |
| Isotype : |
Rabbit IgG |
| Immunogen Information : |
A partial length recombinant HOXA9 protein (amino acids 63-272) was used as the immunogen for this antibody. |
HOXA9�is a well-studied member of the�HOXA�cluster, and it plays a significant role in both normal hematopoiesis and leukemogenesis. HOXA9 is expressed in EC (Endothelial Cells) and its expression is rapidly downregulated during EC activation by inflammatory signals like TNF-alpha (Tumor Necrosis Factor-Alpha) and LPS (lipopolysaccharide) . In humans,�HOXA9�was found to be highly expressed and required in some subtypes of leukemia, particularly mixed lineage leukemia (MLL)-rearranged leukemia. The aberrant overexpression of�HOXA9�is thought to be associated with poor survival of acute myeloid leukemia (AML) patients.
Western blot analysis: 1-2 µg/ml
