|
|
| Gene : |
IL37 |
| Gene ID : |
27178 |
| Uniprot ID : |
Q9NZH6 |
| Alternative Name : |
IL37, FIL1Z, IL1F7, IL1H4, IL1RP1 |
| Format : |
Purified |
| Amount : |
100 µg |
| Isotype : |
Rabbit IgG |
| Immunogen Information : |
Full length recombinant IL-37 protein was used as the immunogen for this antibody. |
IL-37 (Interleukin-37) is a member of IL-1 family and is primarily an anti-inflammatory cytokine, which reduces systemic and local inflammation. There are five different splice variants of IL-37 termed IL-37a-e, where Isoform IL-37b is the largest isoform. IL-37 has significant sequence similarity with IL-18 and highly expressed in inflammatory tissues, which inhibits the excessive inflammatory response. The expression is highly induced by several toll-like receptor (TLR) ligands and pro-inflammatory cytokines such as IL-1beta, TNF-alpha, IFN-gamma. IL-37 is a potent inhibitor of innate immunity by shifting the cytokine equilibrium away from excessive inflammation.
Western blot analysis: 2-4 µg/ml
