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|
Gene : |
IFRD1 |
Gene ID : |
3475 |
Uniprot ID : |
O00458 |
Alternative Name : |
IFRD1 |
Format : |
Purified |
Amount : |
100 µg |
Isotype : |
Rabbit IgG |
Immunogen Information : |
A partial length recombinant Tis7 protein (amino acids 1-300) was used as the immunogen for this antibody. |
Tis7/IFRD1 (interferon-related developmental regulator 1) is expressed by neutrophils as a key modifier gene in cystic fibrosis (CF) lung disease. It functions as a transcriptional co-activator/repressor that controls the growth and differentiation of specific cell types during embryonic development and tissue regeneration. In skeletal muscle cells, Tis7 is known to function as a coactivator of MyoD by promoting the transcriptional activity of myocyte enhancer factor 2C (MEF2C). Mutations in Tis7 are associated with sensory/motor neuropathy with ataxia.
Western blot analysis: 2-4 µg/ml