Polyclonal Antibody to TRK Fused gene

Product code: 11-8031

Clonality : Polyclonal
Application : IHC, WB
Reactivity : Human

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Gene : TFG
Gene ID : 10342
Uniprot ID : Q92734
Alternative Name : TFG
Format : Purified
Amount : 100 µg
Isotype : Rabbit IgG
Immunogen Information : A partial length recombinant TRK Fused gene protein (amino acids 196-400) was used as the immunogen for this antibody.

TRK Fused gene (TFG) encodes a protein that plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. It is a conserved regulator of protein secretion that assembles into an oligomeric matrix at the interface between the ER and ER Golgi intermediate compartments in metazoans cells. Originally TFG was identified as a fusion partner of the NTRK1 gene in human papillary thyroid carcinoma. It is also involved in another chromosome translocation with the ALK gene in anaplastic large-cell lymphomas. It is located on the q arm of human chromosome 3 and encodes a ubiquitously expressed cytoplasmic protein. Structural analysis reveals TFG containing a coiled-coil (CC) domain and a serine, proline, tyrosine, glycine and glutamine (SPYGQ)-rich region. Interestingly, the TFG protein interacts with the NF-kappaB essential modulator and TRAF family member-associated NF-kappaB activator proteins, suggesting that it may play a key role in NF-kappaB regulation.

Purification : Protein A Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.

Western blot analysis:1-2 µg/ml, Immunohistochemical analysis: 20 µg/ml


Polyclonal Antibody to TRK Fused gene

Product code: 11-8031
mg

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