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Gene : |
TFG |
Gene ID : |
10342 |
Uniprot ID : |
Q92734 |
Alternative Name : |
TFG |
Format : |
Purified |
Amount : |
100 µg |
Isotype : |
Rabbit IgG |
Immunogen Information : |
A partial length recombinant TRK Fused gene protein (amino acids 196-400) was used as the immunogen for this antibody. |
TRK Fused gene (TFG) encodes a protein that plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. It is a conserved regulator of protein secretion that assembles into an oligomeric matrix at the interface between the ER and ER Golgi intermediate compartments in metazoans cells. Originally TFG was identified as a fusion partner of the NTRK1 gene in human papillary thyroid carcinoma. It is also involved in another chromosome translocation with the ALK gene in anaplastic large-cell lymphomas. It is located on the q arm of human chromosome 3 and encodes a ubiquitously expressed cytoplasmic protein. Structural analysis reveals TFG containing a coiled-coil (CC) domain and a serine, proline, tyrosine, glycine and glutamine (SPYGQ)-rich region. Interestingly, the TFG protein interacts with the NF-kappaB essential modulator and TRAF family member-associated NF-kappaB activator proteins, suggesting that it may play a key role in NF-kappaB regulation.
Western blot analysis:1-2 µg/ml, Immunohistochemical analysis: 20 µg/ml