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| Alternative Name : |
Troponin C slow skeletal and cardiac muscles, TN-C, TNNC1, TNNC, TNC, CMD1Z. |
| Amount : |
100 µg |
Source : Escherichia Coli.
Recombinant Human TNC produced in E.Coli is a single, non-glycosylated, polypeptide chain having a molecular mass of 18,020 Dalton.The TNC is purified by proprietary chromatographic techniques.
Troponin is a fundamental regulatory protein of striated muscle contraction, and together with tropomyosin, is positioned on the actin filament. Troponin has 3 subunits: TnI- the inhibitor of actomyosin ATPase; TnT- contains the binding site for tropomyosin; and TnC- the protein encoded by the TNNC1 gene. The binding of calcium to TnC stops the inhibitory action of TnI, consequently allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in the TNNC1 gene are linked to cardiomyopathy dilated type 1Z.
