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| Alternative Name : |
Keratin 17, PCHC1, 39.1, CK-17, K17, PC2, PC, cytokeratin-17,
Keratin 17 Epitope S1, Keratin 17 Epitope S2, Keratin 17 Epitope S4, Keratin,
Type I Cytoskeletal 1, keratin-17, Cytokeratin-17, Keratin-17. |
| Amount : |
20 µg |
Source : Escherichia Coli.
KRT17 Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 455 amino acids (1-432 a.a) and
having a molecular mass of 50.5kDa.KRT17 is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Cytokeratin
17 also known as KRT17 is a type I cytokeratin. KRT17 is found in nail beds,
hair follicles, sebaceous glands, and other epidermal appendages. Mutations in
KRT17 lead to Jackson-Lawler type pachyonychia congenita and steatocystoma
multiplex. KRT17 takes part in the formation and maintenance of a variety of
skin appendages, particularly in determining shape and orientation of hair. KRT17
also modulates the function of TNF-alpha in the precise context of hair
cycling. Moreover, KRT17 regulates protein synthesis and epithelial cell growth
all through binding to the adapter protein SFN and by stimulating Akt/mTOR
pathway.
