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Alternative Name : |
JIP, DPC4, MADH4, SMAD-4, DPC-4, MADH-4, Mothers against decapentaplegic homolog 4, Mothers against DPP homolog 4, SMAD 4, hSMAD4, Deletion target in pancreatic carcinoma 4, SMAD4, SMAD family member 4. |
Amount : |
50 µg |
Source : Escherichia Coli.
SMAD4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 572 amino acids (1-552) and having a molecular mass of 62.6 kDa. SMAD4 is fused to a 20 amino acid His-Tag at N-Terminus and purified by standard chromatography techniques.
SMAD4 is part of the SMAD family of proteins that mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD4 promotes the binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides the function of activation required for SMAD1 or SMAD2 to stimulate transcription acts as a tumor suppressor. SMAD4 is a target molecule for functional inactivation in cervical cancer. SMAD4 is an important biomarker for malignant transformation atakes part in inducing apoptosis by modulating Bcl-2/Bax balance.