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Alternative Name : |
MYC Induced Nuclear Antigen, MINA53, MDIG, 60S Ribosomal
Protein L27a Histidine Hydroxylase, Mineral Dust-Induced Gene Protein, Histone
Lysine Demethylase MINA
Ribosomal Oxygenase MINA, Nucleolar Protein 52, NO52, ROX,
Bifunctional Lysine-Specific |
Amount : |
10 µg |
Source : Escherichia Coli.
MINA Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 485 amino acids (1-465 a.a) and
having a molecular mass of 54.9kDa.
MINA is fused to a 20 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
MYC Induced Nuclear Antigen, also known as MINA is an oxygenase which
can function both as a histone lysine demethylase and a ribosomal histidine hydroxylase. MINA is involved in the demethylation of trimethylated
Lys-9 on histone H3 (H3K9me3), leading to an increase in ribosomal RNA
expression. MINA also catalyzes the
hydroxylation of 60S ribosomal protein L27a on His-39. In addition, MINA plays a significant role in cell growth and
survival. MINA is implicated in ribosome
biogenesis, probably in the duration of the assembly process of pre-ribosomal
particles.