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| Alternative Name : |
NANOG, Homeobox protein NANOG, Homeobox transcription factor Nanog, hNanog. |
| Amount : |
20 µg |
Source : Escherichia Coli.
NANOG Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 305 amino acids and having a molecular mass of 34.6kDa.The NANOG is fused to an N-terminal TAT (transcriptional activator protein) tag and purified by proprietary chromatographic techniques.
NANOG is a multidomain homeobox transcription factor which functions to maintain the undifferentiated state of pluripotent stem cells. NANOG expression counteracts the differentiation-promoting signals induced by the extrinsic factors LIF, Stat3 and BMP. Once NANOG expression is downregulated, cell differentiation can proceed. Proteins which regulate NANOG expression include transcription factors Oct4, SOX2, FoxD3, and Tcf3 and tumor suppressor p53.
It is recommended to reconstitute the lyophilized NANOG in sterile PBS not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
