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| Alternative Name : |
Neuronal Calcium Sensor 1, Frequenin-Like Ubiquitous
Protein, Frequenin-Like Protein, Frequenin Homolog, FREQ, FLUP, Frequenin
(Drosophila) Homolog, Frequenin Homolog (Drosophila), FREQ, NCS-1, Neuronal
calcium sensor 1. |
| Amount : |
20 µg |
Source : Escherichia Coli.
NCS1 213 a.a. Human Recombinant produced in E.Coli is a
single, non-glycosylated polypeptide chain containing 213 amino acids (1-190 a.a)
and having a molecular mass of 24.3kDa.
NCS1 213 a.a. is fused to a 23 amino acid His-tag at
N-terminus & purified by proprietary chromatographic techniques.
NCS1 is part of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed primarily in neurons. NCS1 regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. NCS1 is related with secretory granules and modulates synaptic transmission and synaptic plasticity. NCS1 regulates GRK1 and substitutes for calmodulin. NCS1 stimulates PI4KB kinase activity and participates in long-term synaptic plasticity through its interaction with PICK1. NCS1 takes part in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.
