|
|
| Alternative Name : |
Paired Box 8, Paired Box Gene 8, PAX8. |
| Amount : |
10 µg |
Source : Escherichia Coli.
PAX8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 310 amino acids (1-287 a.a) and having a molecular mass of 33.4kDa.PAX8 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Paired box 8,
also known as PAX8 functions in thyroid follicular cell development as well as
in expression of thyroid-specific genes. PAX8 complexes with TTF-1 & TTF-2 in
order to stimulate thyroid follicular cell differentiation and thyroid hormone
biosynthesis by regulating the expression of NIS (sodium iodide symporter) , TPO (thyroid
peroxidase), TG (thyroglobulin) and the TSHR (thyrotropin receptor). Defects in PAX8 are the cause of CHNG2 (congenital
hypothyroidism non-goitrous type 2).
