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| Alternative Name : |
Phospholipid scramblase 3, PL scramblase 3, Ca(2+)-dependent
phospholipid scramblase 3. |
| Amount : |
25 µg |
Source : Escherichia Coli.
PLSCR3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 288 amino acids (1-265 a.a) and having a molecular mass of 30.9kDa.PLSCR3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Phospholipid
Scramblase 3, (PLSCR3) may mediate accelerated ATP-independent bidirectional
transbilayer migration of phospholipids upon binding calcium ions which results
in a loss of phospholipid asymmetry in the plasma membrane. PLSCR3
may play a key role in the initiation of fibrin clot formation, in the
activation of mast cells and in the recognition of apoptotic and injured cells
by the reticuloendothelial system. In addition, PLSCR3 seems to play a role in
apoptosis, through
translocation of cardiolipin from the inner to the outer mitochondrial membrane
which promotes BID recruitment and enhances tBid-induced mitochondrial damages.
Among the diseases associated with PLSCR3 are brain ischemia, and ischemia.
