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| Alternative Name : |
PIM, Serine/threonine-protein kinase pim-1, PIM1. |
| Amount : |
10 µg |
Source : E.coli.
PIM1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 274 amino acids (38-290 a.a.) and having a molecular mass of 31.4kDa. PIM1 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
PIM1, which is a part of the Ser/Thr protein kinase family and PIM subfamily, is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. PIM1 functions as Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation, consequently providing a selective advantage in tumorigenesis. Both human and orthologous mouse genes have been reported to encode two isoforms resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons.
