|
|
| Gene : |
PCBP1 |
| Gene ID : |
5093 |
| Uniprot ID : |
Q15365 |
| Alternative Name : |
Poly(rC) binding protein 1, hnRNP-E1, hnRNP-X, HNRPE1,
HNRPX, Alpha-CP1, Heterogeneous nuclear ribonucleoprotein E1, Nucleic
acid-binding protein SUB2.3, PCBP1. |
| Format : |
Purified |
| Amount : |
20 µg |
| Clone name : |
PAT2A10AT |
| Isotype : |
Mouse IgG2a heavy chain and k light chain. |
| Immunogen Information : |
Anti-human PCBP1 mAb,
clone PAT2A10AT, is derived from hybridization of mouse F0 myeloma cells with
spleen cells from BALB/c mice immunized with a recombinant human PCBP1 protein 1-163
amino acids purified from E. coli. |
PCBP1 is a single-stranded nucleic acid binding protein that binds preferentially to oligo dC. PCBP1 plays a role in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. PCBP1 along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. PCBP1 and PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promotes poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure.
The antibody has been tested by ELISA, Western blot
analysis to assure specificity and reactivity. Since application varies,
however, each investigation should be titrated by the reagent to obtain optimal
results. Recommended starting dilution is 1:500.
