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| Alternative Name : |
Sm-F, Sm protein F, snRNP-F, SMF, PBSCF, Small Nuclear Ribonucleoprotein Polypeptide F. |
| Amount : |
20 µg |
Source : Escherichia Coli.
SNRPF produced in E.Coli is a single, non-glycosylated polypeptide chain containing 106 amino acids (1-86a.a.) and having a molecular mass of 11.8kDa.SNRPF is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
SNRPF is a member of the snRNP Sm proteins family. There are at least seven isoforms, E, F, G, D1, D2, D3 and B/B. This type of common proteins have a crucial part in the biogenesis of the snRNPs. Moreover, they represent the major targets for the so-called anti-Sm auto-antibodies that are diagnostic for systemic lupus erythematosus (SLE). SNRPF assist in the cytoplasmic construction of the UsnRNPs by binding to aconserved Sm site on UsnRNA and forming a stable snRNP core complex.
