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| Alternative Name : |
SWI/SNF Related, Matrix Associated, Actin Dependent
Regulator Of Chromatin, Subfamily A, Member 4, Mitotic Growth And Transcription
Activator, ATP-Dependent Helicase SMARCA4, BRG1, Global Transcription Activator
Homologous Sequence
Sucrose Nonferme |
| Amount : |
20 µg |
Source : Escherichia Coli.
SMARCA4 Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 211 amino acids (362-549aa) and
having a molecular mass of 25kDa.
SMARCA4 is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
SMARCA4 belongs to the SWI/SNF family of proteins and is similar to the
brahma protein of Drosophila.
Proteins in this family have helicase and ATPase activities and are considered
to regulate transcription of
certain genes by altering the chromatin structure around those genes. SMARCA4
is part of the large ATP-dependent chromatin
remodeling complex SNF/SWI, which is essential for transcriptional activation of genes normally repressed by chromatin. In
addition, SMARCA4 is able to bind BRCA1, as well as regulating the expression
of the
tumorigenic protein CD44. Moreover, mutations in SMARCA4 cause rhabdoid tumor
predisposition syndrome type 2.
