|
|
| Alternative Name : |
Snail Family Zinc Finger 1, Protein
Sna, Protein Snail Homolog 1, SNAH, Snail 1 (Drosophila Homolog), Zinc Finger
Protein, Snail Homolog 1 (Drosophila), SLUGH2, SNA, SNAIL, SNAIL1, dJ710H13.1, Snail
1 Homolog, Snail 1 Zinc Finger Protein, Snail 1, Zi |
| Amount : |
20 µg |
Source : Escherichia Coli.
SNAI1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 287 amino acids (1-264 a.a) and having a molecular mass of 31.5kDa.SNAI1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Snail
homolog 1 (SNAI1) is involved in induction of the epithelial to mesenchymal
transition (EMT), formation and maintenance of embryonic mesoderm, growth
arrest, survival and cell migration. SNAI1 binds to 3 E-boxes of the E-cadherin
gene promoter
and represses its transcription. The nuclear protein encoded by SNAI1 is
structurally identical to the Drosophila snail protein, and is considered as
well to be vital for mesoderm formation in the developing embryo. At least two
variants of a similar processed pseudogene have been found on chromosome 2. Among the diseases associated with SNAI1 are waardenburg
syndrome type iid, and inappropriate adh syndrome.
