|
|
| Alternative Name : |
Suppressor Of IKBKE 1, SIKE, Suppressor Of IKK Epsilon, Suppressor
Of IKK-Epsilon. |
| Amount : |
10 µg |
Source : Escherichia Coli.
SIKE1 Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 230 amino acids (1-207 a.a) and
having a molecular mass of 26.1kDa.SIKE1 is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Suppressor of
IKBKE 1 also known as SIKE1 belongs to the SIKE family. SIKE interacts with
IKK-epsilon and TBK1 and function as a suppressor of TLR3 and virus-triggered
interferon activation pathways.
In addition, SIKE1 perform by disrupting the interactions of IKBKE or TBK1 with
TICAM1/TRIF, IRF3 andDDX58/RIG-I. SIKE1 does not inhibit NF-kappa-B activation
pathways.
