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|
Alternative Name : |
ALS10,
TDP43, TAR DNA-binding protein 43, TDP-43, TARDBP. |
Amount : |
20 µg |
Source : E.coli.
TARDBP Human Recombinant produced in E.Coli is a single,
non-glycosylated, polypeptide chain containing 450 amino acids (1-414 a.a) and
having a total molecular mass of 48.8 kDa. TARDBP is fused to a 36 amino acid His-tag at
N-terminus & purified by proprietary chromatographic techniques.
TAR
DNA Binding Protein (TARDBP) was initially recognized as a transcriptional repressor
which binds to chromosomally integrated TAR DNA and represses HIV-1
transcription. In addition, TARDBP has been detected in individuals diagnosed
with chronic traumatic encephalopathy as well, which is a condition that often
imitates ALS and has
been related with athletes who have experienced multiple concussions and other
types of head injury.TARDBP
has been shown to bind both DNA and RNA, it has multiple functions in
transcriptional repression, pre-mRNA splicing and translational regulation.