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| Alternative Name : |
Receptor-Associated Protein Of The Synapse, 43 KDa
Postsynaptic Protein, Acetylcholine Receptor-Associated 43 KDa Protein, RNF205,
RING Finger Protein 205, rapsyn, Receptor-Associated Protein Of The Synapse,
43Kd, 43 KDa Receptor-Associated Protein O |
| Amount : |
20 µg |
Source : Escherichia Coli.
RAPSN Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 435 amino acids (1-412aa) and having a molecular mass of 48.8kDa.RAPSN is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
43
kDa receptor-associated protein of the synapse (RAPSN), is expressed in the postsynaptic
membrane of skeletal muscle. RAPSN is essential for the clustering of nicotinic
acetylcholine receptors (nAChR). In addition RAPSN self-associates via at least
two of its seven tetra-tricopeptide repeats (TPRs). RAPSN interacts with
the large intracellular domain of the nAChR a subunit all the way through the
hydrophobic surface of the coiled-coil domain.
RAPSN modifies trafficking of AChR within the cell. Overexpression
inhibits agrin-induced AChR clustering pathway. RAPSN also plays a role in
postsynaptic congenital myasthenic syndromes.
