|
|
| Gene : |
ERBB2 |
| Gene ID : |
2064 |
| Uniprot ID : |
P04626 |
| Alternative Name : |
ERBB2, HER2, MLN19, NEU, NGL |
| Amount : |
50 µg |
| Isotype : |
Camelid VHH |
Alpaca derived anti-HER2 VHH single domain antibody (molecular weight:14.1 kDa) with a 6*His tag at its C-terminal, expressed in E. coli under conditions free from animal derived components.
Receptor tyrosine-protein kinase erbB-2, also known as Her2, is a protein that in humans is encoded by the ERBB2 gene. The ErbB family consists of four closely related tyrosine kinase receptors that act as potent mediators of normal cell growth and development. Aberrant expression or function of one or more of these receptors can play a major role in the development and evolution of cancer. Her2 has been implicated in the evolution of both breast and gastric cancers, and is evident in other cancer types such as ovarian and salivary gland tumors. Her2 possesses an active tyrosine kinase domain, but no direct ligand has been identified yet. Her2 is the preferred binding partner to the other members of the ErbB family and is thought to act primarily through the Ras-MAPK, PI3k-PKB/Akt, and PLC-PKC signalling pathways.
Specificity: Receptor tyrosine-protein kinase erbB-2 (HER2)
This is a product from Jotbody, Hong Kong. This antibody is made available by ABGENEX.
Positive controls Positive IHC detected in: human lung carcinoma tissue Positive IF detected in: MCF-7 cells.
Recommended dilutions IHC 1:200-1:600 IF 1:200-1:600
