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| Alternative Name : |
Four And A Half LIM Domains 3, SLIM2, Skeletal Muscle
LIM-Protein 2, FHL-3, SLIM-2, Four And A Half LIM Domains Protein 3, LIM-Only
Protein FHL3. |
| Amount : |
10 µg |
Source : Escherichia Coli.
FHL3 Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 303 amino acids (1-280 a.a) and
having a molecular mass of 33.6kDa. FHL3 is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Four
and a half LIM domains 3 (FHL3) belongs to a family of proteins containing a
four-and-a-half LIM domain, which is a highly conserved double zinc finger
motif. FHL3 has been shown to interact with the cancer developmental regulators
SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the
high-affinity IgE beta chain regulator MZF-1. FHL3 is involved in tumor
suppression, repression of MyoD expression, and repression of IgE receptor
expression. Two transcript variants encoding different isoforms have been found
for this gene.
