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Alternative Name : |
TSD, hexosaminidase A, Beta-hexosaminidase subunit alpha,
Beta-N-acetylhexosaminidase subunit alpha, Hexosaminidase subunit A, N-acetyl-beta-glucosaminidase
subunit alpha. |
Amount : |
20 µg |
Source : Escherichia Coli.
HEXA Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 464 amino acids (89-529 a.a) and having a molecular mass of 52.9 kDa.HEXA is fused to a 23 amino acid His-tag at N-terminus.
HEXA is the alpha subunit of the lysosomal enzyme
beta-hexosaminidase which, combined with the cofactor GM2 activator protein,
catalyzes the degradation of the ganglioside GM2, and other molecules having
N-acetyl hexosamines terminus. The two subunits composing Beta-hexosaminidase,
alpha and beta, belong to the glycosyl hydrolases family and are encoded by
distinct genes. Alpha subunit gene mutations can cause Tay-Sachs disease
(GM2-gangliosidosis type I).