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Gene : |
CD6 |
Gene ID : |
923 |
Uniprot ID : |
P30203 |
Alternative Name : |
CD6 |
Format : |
Purified |
Amount : |
100 µg |
Clone name : |
SPM547 |
Isotype : |
Mouse IgG1, kappa |
Immunogen Information : |
Human recombinant CD6 protein |
CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular ?scavenger receptor cysteine-rich? (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.
Immunofluorescence (1-2ug/ml); ,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);