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|
| Gene : |
CLEC4E |
| Gene ID : |
26253 |
| Uniprot ID : |
Q9ULY5 |
| Alternative Name : |
CLEC4E, CLECSF9, MINCLE, UNQ218/PRO244 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ABM42C6 |
| Isotype : |
Mouse IgG1 Kappa |
| Immunogen Information : |
A full length human CLEC4E protein was used as the immunogen for this antibody. |
CLEC4E (C-type lectin domain family 4, member E), also called as Mincle, is a type II transmembrane C-type lectin receptor that specifically binds to the cord factor TDM (trehalose-6,6?-dimycolate), a unique glycolipid of mycobacterial cell-surface components, and activates immune cells to confer adjuvant activity. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. CLEC4E is mainly expressed in myeloid cells, such as macrophages and neutrophils and possesses a single carbohydrate-recognition domain (CRD) in the extracellular region. It is associated with FcRgamma chain, an immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor, and acts as an activating receptor that senses damaged cells. CLEC4E is also a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPbeta) and may play a role in inflammation.
Western blot analysis: 2-4 µg/ml, Flowcytometric analysis: 0.5-1 µg/10^6 cells
