|
|
| Gene : |
IL1RL2 |
| Gene ID : |
8808 |
| Uniprot ID : |
Q9HB29 |
| Alternative Name : |
IL1RL2, IL1RRP2 |
| Format : |
Purified |
| Amount : |
100 µg |
| Clone name : |
ABM47A2 |
| Isotype : |
Mouse IgG2b, kappa |
| Immunogen Information : |
A partial length recombinant IL-36R protein (amino acids 1-203) was used as the immunogen for this antibody. |
IL-36R is a member of the IL-1 receptor family that has been associated with various inflammation-associated diseases. Ligands binding to IL-36R subsequently recruit the IL-1RAcP (IL-1 Receptor Accessory Protein) forming a heterodimeric signaling complex. The latter is also used by IL-1Alpha and IL-1Beta. IL-36R is expressed by different immune cells, including Dendritic Cells, microglia and other myeloid cells. IL-36 stimulation of DC leads to the production of several cytokines by DC, including TNF-a, IL-1, IL-12, and IL-23. This interaction also enhances the expression of MHC class 2 and co-stimulatory molecules.
Western blot analysis: 2-4 µg/ml, Flowcytometric analysis: 0.5-1 µg/10^6 Cells
