Monoclonal antibody to LAMP1 (Clone: ABM5F15)

LAMP1 (Lysosomal-Associated Membrane Protein-1) is among the most abundant lysosomal membrane proteins being a heavily glycosylated protein creating a sugar coat or glycocalyx on the inner side of the lysosomal membrane aiding to the protection of the membrane from the hydrolytic enzymes and degradation. LAMP1 is expressed mainly in the endosome-lysosomal membrane of cells but has also been found in the plasma membrane (1-2% of total LAMP1). It has been found on the cell surface of highly metastatic tumor cells and especially metastatic colon cancer cells showed a high expression of LAMP1 compared to cancer cells with low metastatic potential, suggesting a role for LAMP1 in cell-cell adhesion and migration. LAMP1 is widely used as a marker for the identification of NK-cell degranulation, as it appears on the cell surface following the fusion of lysosomes with the plasma membrane, the role of LAMP1 in NK-cell biology is unknown.

Western blot analysis: 2-4 µg/ml