|
|
| Gene : |
CDH1 |
| Gene ID : |
999 |
| Uniprot ID : |
P12830 |
| Alternative Name : |
CDH1, CDHE, UVO |
| Format : |
Purified |
| Amount : |
100 µg |
| Isotype : |
Rabbit IgG |
| Immunogen Information : |
A partial length recombinant E-cadherin protein (amino acids 438-556) was used as the immunogen for this antibody . |
E-cadherin is a calcium-regulated adhesion molecule expressed in most normal epithelial tissues. It is localized on the surfaces of epithelial cells in regions of cell-cell contact known as adherens junctions. The E-cadherin gene is located on chromosome 16q22.1. E-cadherin is associated with gland formation, stratification, and epithelial polarization. Besides its role in normal cells, this highly conserved gene can play a major role in malignant cell transformation, and especially in tumor development and progression. Selective loss of E-cadherin can cause dedifferentiation and invasiveness in human carcinomas, leading E-cadherin to be classified as a tumor suppressor.
Western blot analysis: 2-4 µg/ml
