|
|
| Gene : |
KLF10 |
| Gene ID : |
7071 |
| Uniprot ID : |
Q13118 |
| Alternative Name : |
KLF10, TIEG, TIEG1 |
| Format : |
Purified |
| Amount : |
100 µg |
| Isotype : |
Rabbit IgG |
| Immunogen Information : |
A partial length recombinant KLF10 protein (amino acids 11-221) was used as the immunogen for this antibody. |
Kruppel-like factor 10 (KLF10 ) is a member of the Kr�ppel-like family of transcription factors, which are known to be involved in anti-proliferative and apoptotic inducing functions following TGF-beta induction. KLF10 plays an important role in the repression of proliferative and hypertrophic pathways, possibly through the actions of PTTG1 (pituitary tumor-transforming gene 1). KLF10 is found to be predominantly expressed in various tissues and its expression is regulated by cytokines and growth factors. Over-expression of KLF10 has been found to induce apoptosis in pancreatic cancer cells. In addition, KLF10 induces apoptosis via a mechanism which involves the formation of reactive oxygen species.
Western blot analysis: 1-2 µg/ml
